Stories & Features

Every time a traditional UHPLC valve is rotated to make an injection in a UHPLC system, the pressure of the mobile phase flowing through the column fluctuates. When switching from load to inject, the system experiences a 11,000 psi (758 bar, 76 MPa) pressure drop. In addition to the injection pressure drop, the column also experiences a pressure drop when the valve switches back to the load position from the inject position. Over time when switching the valve repeatedly, these pressure drops can disrupt column packing and cause the column to experience an early lifetime failure.
Full story

During reagent handling or at the connection junctions, even small changes in the fluid path can cause dissolved gasses to occur in a solution. Factors including pressure, temperature, and chemical mixing are sources of bubble formation. Bubbles in the fluid stream cause detection variables, which can produce unstable, wandering, or noisy baselines. How do you prevent these variable changes in your fluid path? A Degasser
Full story

Fluidic applications with multiplexed reagents tend to result in complicated system designs and manufacturing. If each flow path is not carefully developed, your system will be vulnerable to leaking or kinks, and can trigger a myriad of obstacles such as increased system-volume, excess heat generation, and inaccurate results.
Full story

How do you handle customized fluidic design iterations when you are on a tight timeline and budget? In fluidic pathway development, the most efficient way to optimize your system is to integrate a manifold to reduce device size, decrease leaks, and add valves and pumps. This will improve reliability of the flow path and provide consistent performance.
Full story