Stories & Features

Are you running highly sensitive organic solvents through your UHPLC system? We have designed a bioinert tubing and fitting connection system called, MarvelXACT™ PEEKsil™, with tubing that provides both the chemical compatibility of fused silica glass and the strength of PEEK.
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As diagnostic testing kits are designed to make test procedures as straightforward and robust as possible, point-of-care solutions have become increasingly common. This allows for increased compliance and more frequent testing results to keep individuals healthy. As we fight this coronavirus pandemic, an easy-to-use test would be highly desirable for COVID-19, given the immense pressures on the healthcare system.
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A good lab practice tip is to make the replacement of your filters or frits a part of your system’s preventative maintenance routine. Typically maintenance occurs every six months to one year. There will be times when you will need to change your filter or frit in addition to the regularly-scheduled changes.
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MarvelX UHPLC connection systems have been expertly designed for easy routing throughout your instrument, while providing consistent performance and superior re-usability. The connection system is compatible with 10-32 coned receiving ports and is absolutely finger-tight — no tool required.
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Fittings are typically comprised of a nut and a ferrule and have the important function of providing the physical connection of tubing throughout most systems. While simple in function, fittings exhibit some complexity regarding their description and how they are used.
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When analytical scientists review their HPLC laboratory set-ups, they typically have a couple goals in mind. How can we enhance the performance of the system and produce repeatable, certifiable results? What methods could we implement to increase the efficiency of the system? To work through these goals, an often overlooked but key element to consider is the degasser.
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Businesses in the analytical laboratory market are constantly looking for modern management and productivity processes to adopt. Methods are increasingly developed using QbD (Quality by Design) principles and are subject to active life cycle management. The main goals of innovating and adopting new technologies include repeatable and certifiable performance, maximum efficiency and cost-effective operation, along with improved environmental awareness.
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Utilize degassing in your fluidic path to remove dissolved gases from fluids before they outgas and form problem-causing bubbles.
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Life Science instrument designers face many challenges when incorporating a fluid delivery system into an instrument. Many instruments on the market use a single positive displacement dispense pump because they are compact and easy to integrate. These systems force designers to make multiple compromises because pump displacement volume, pressure handling, flow rate, and flow duration are all interrelated. How can you achieve accurate, stable flow rates with unlimited flow in your liquid chromatography and mass spectrometry instruments?
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Every time a traditional UHPLC valve is rotated to make an injection in a UHPLC system, the pressure of the mobile phase flowing through the column fluctuates. When switching from load to inject, the system experiences a 11,000 psi (758 bar, 76 MPa) pressure drop. In addition to the injection pressure drop, the column also experiences a pressure drop when the valve switches back to the load position from the inject position. Over time when switching the valve repeatedly, these pressure drops can disrupt column packing and cause the column to experience an early lifetime failure.
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