Seamlessly Integrate Innovative Fluidic Technology into Your Mass Spec Workflow
Lack of real-time CQA/CPP data from cell culture process is a pain point that adds time and complexity to biotherapeutic drug development. This presents a massive challenge to the commercialization of the growing number of promising therapies in the development pipeline, however, it opens an opportunity for innovation.
IDEX Health & Science can help automate end-to-end workflows–from bioreactor to mass spec source, bridging the gap between the cell culture process and analytical instrumentation at all scales; from R&D to manufacturing. We partner with life science instrument manufacturers to develop innovative, consistent, and easy to integrate solutions for challenging analytical workflows in biopharma. Partner with us to make your vision a reality and accelerate your biopharmaceutical development.
Key Capabilities
- Technology to address pain points and automation for numerous applications in bioprocessing PAT
- We enable automated end-to-end workflows from bioreactor to analyzer
- Capabilities for mAb sample clean-up and processing including spent media, glycan, peptide, and multi-attribute methods
- We seamlessly integrate our components and subsystems into OEM platforms
Use the quick links below to find more information about our mass spec workflows:
Partner with Us
The analytical challenges of biological drug development are immense, but we can streamline your workflows, improve performance, provide consistency, and accelerate your time to market.
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mAb Sample Preparation
IDEX Health & Science can automate pipette-free, inline mAb sample prep for key workflows such as glycan analysis, peptide mapping, and multi-attribute methods (MAM). Our custom solutions can be tailored to any commercially available reagent kit including magnetic bead chemistry.
IDEX Health & Science Capabilities
- Inline magnetic bead manipulation
- Inline temperature-controlled reaction zones
- Custom valve design
- Bioinert flow paths
- Integration into OEM platforms
Key Benefits
- Walkaway automation of mAb sample prep
- Eliminates human error caused by pipetting
- Improves reproducibility
- Enables online MAM workflows
Inline solutions are a hands-free alternative to tedious pipette-based mAb sample prep workflows
Automated Calibration for mAb Titer
Calibration can be one of the most tedious steps in any analytical workflow. IDEX Health & Science can create integration-ready solutions to automate calibration for mAb titer.
IDEX Health & Science Capabilities
- Compact LED UV detection
- Accurate fluid dispensing
- Bioinert flow paths
- Integration into OEM platforms
Key Benefits
- Enables walkaway calibration for mAb quantification workflows
- Simplifies real-time monitoring for process control and modelling
Simple fluidic subsystem for automated Protein A calibration
Cell Culture Media Analysis
Cell culture media analysis using CE-MS or LC-MS provides critical insight into cell health and productivity. IDEX Health & Science can create a pipette-free alternative to time-consuming manual precipitation dilution typically required for these methods.
IDEX Health & Science Capabilities
- Accurate fluid dispensing
- Custom valve design
- Bioinert flow paths
- Smart system feedback
- Integration into OEM platforms
Key Benefits
- Hands-free inline sample preparation
- Simplifies real-time monitoring for process control and modelling
- Environmentally friendly: 100% aqueous-based with no acetonitrile or harmful organic solvents
Inline sample prep subsystem for cell culture media analysis
Smart Intact Mass Analysis
IDEX Health & Science can create custom subsystems to combine UV titer with intact mass analysis for a unified workflow. This is accomplished by an integrated buffer exchange procedure to prepare a sample for ionization in a mass spectrometer source.
IDEX Health & Science Capabilities
- Custom valve design
- Complete bioinert flow paths
- Accurate fluid dispensing
- Integration into OEM platforms
Key Benefits
- Unified workflow for mAb product quantification and identification
- Enables simpler GMP traceability
Buffer exchange for unified mAb titer and intact mass
