Seamlessly Integrate Innovative Fluidic Technology into Your Mass Spec Workflow
Lack of real-time CQA/CPP data from cell culture process is a pain point that adds time and complexity to biotherapeutic drug development. This presents a massive challenge to the commercialization of the growing number of promising therapies in the development pipeline, however, it opens an opportunity for innovation.
IDEX Health & Science can help automate end-to-end workflows–from bioreactor to mass spec source, bridging the gap between the cell culture process and analytical instrumentation at all scales; from R&D to manufacturing. We partner with life science instrument manufacturers to develop innovative, consistent, and easy to integrate solutions for challenging analytical workflows in biopharma. Partner with us to make your vision a reality and accelerate your biopharmaceutical development.
Key Capabilities
- Technology to address pain points and automation for numerous applications in bioprocessing PAT
- We enable automated end-to-end workflows from bioreactor to analyzer
- Capabilities for mAb sample clean-up and processing including spent media, glycan, peptide, and multi-attribute methods
- We seamlessly integrate our components and subsystems into OEM platforms
Partner with Us and Get Updates
The analytical challenges of biological drug development are immense, but we can streamline your workflows, improve performance, provide consistency, and accelerate your time to market.
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Use the quick links below to find more information about our mass spec workflows:
mAb Sample Preparation Automated Calibration for mAb Titer Cell Culture Media Analysis Smart Intact Mass Analysis
mAb Sample Preparation
IDEX Health & Science can automate pipette-free, inline mAb sample prep for key workflows such as glycan analysis, peptide mapping, and multi-attribute methods (MAM). Our custom solutions can be tailored to any commercially available reagent kit including magnetic bead chemistry.
IDEX Health & Science Capabilities
- Inline magnetic bead manipulation
- Inline temperature-controlled reaction zones
- Custom valve design
- Bioinert flow paths
- Integration into OEM platforms
Key Benefits
- Walkaway automation of mAb sample prep
- Eliminates human error caused by pipetting
- Improves reproducibility
- Enables online MAM workflows
Inline solutions are a hands-free alternative to tedious pipette-based mAb sample prep workflows
Automated Calibration for mAb Titer
Calibration can be one of the most tedious steps in any analytical workflow. IDEX Health & Science can create integration-ready solutions to automate calibration for mAb titer.
IDEX Health & Science Capabilities
- Compact LED UV detection
- Accurate fluid dispensing
- Bioinert flow paths
- Integration into OEM platforms
Key Benefits
- Enables walkaway calibration for mAb quantification workflows
- Simplifies real-time monitoring for process control and modelling
Simple fluidic subsystem for automated Protein A calibration
Cell Culture Media Analysis
Cell culture media analysis using CE-MS or LC-MS provides critical insight into cell health and productivity. IDEX Health & Science can create a pipette-free alternative to time-consuming manual precipitation dilution typically required for these methods.
IDEX Health & Science Capabilities
- Accurate fluid dispensing
- Custom valve design
- Bioinert flow paths
- Smart system feedback
- Integration into OEM platforms
Key Benefits
- Hands-free inline sample preparation
- Simplifies real-time monitoring for process control and modelling
- Environmentally friendly: 100% aqueous-based with no acetonitrile or harmful organic solvents
Inline sample prep subsystem for cell culture media analysis
Smart Intact Mass Analysis
IDEX Health & Science can create custom subsystems to combine UV titer with intact mass analysis for a unified workflow. This is accomplished by an integrated buffer exchange procedure to prepare a sample for ionization in a mass spectrometer source.
IDEX Health & Science Capabilities
- Custom valve design
- Complete bioinert flow paths
- Accurate fluid dispensing
- Integration into OEM platforms
Key Benefits
- Unified workflow for mAb product quantification and identification
- Enables simpler GMP traceability
Buffer exchange for unified mAb titer and intact mass
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